Laboratory of Translational Oncology

PROFILE

The research of our team focuses on biology of cancer, especially on better understanding of factors underlying metastatic spread, particularly in cancer cell dissemination via lymphatic and hematogenous route. This includes dissecting the role of tumor-stroma crosstalk, profiling circulating tumor cells (CTCs), circulating tumor DNA (ctDNA) and tumour educated platelets (TEPs). We are interested in discovering the role of epithelial-mesenchymal phenotypic plasticity on tumour cells malignancy and cancer progression. The laboratory is specializing in the analysis of tumor cells at genomic and transriptomic level using qPCR, next generation sequencing or NanoString, also at single cell-level. We apply multi-color imaging with standard immunofluorescence or high throughput techniques such as Image Stream for profiling of CTCs and immunochistochemical profiling of tissues.  Our team is experienced in carrying out projects related to biobanking, development and validation of novel blood-based assays, diagnostic or prognostic biomarkers in order to monitor disease progression and response to the therapy more precisely. In our interdisciplinary projects we collaborate closely with clinicians, pathologists, statisticians and molecular biologists in order to obtain multifaceted view on cancer. The research of the team is situated at the edge of molecular biology and clinical oncology with mission to translate results obtained in the laboratory into clinical practice, contributing to more effective individualized patient management.

RESEARCH TEAM

Laboratory Of Translational Oncology

Intercollegiate Faculty of Biotechnology UG&MUG
Dębinki 1 Street, 80-211 Gdańsk, Poland

Secretariat:
Agnieszka Romel-Zielke [e-mail] 
​Tel.:+48 58 349 14 38

team zaczek
photo: Paweł Sudara 

Head: prof. Anna Żaczek [link]
Tel.: +48 58 349 1410 [e-mail]

List of Employees and PhD students:

dr Natalia Bednarz-Knoll
tel:.: +48 58 349 1438 [e-mail]
dr Aleksandra Markiewicz
tel.: +48 58 349 1438 [e-mail]
dr Anna Supernat
tel.:: +48 58 349 1438 [e-mail]
dr Paulina Nastały
tel.: +48 58 349 1438 [e-mail]
dr Kamil Myszczyński
tel.: +48 58 349 1438 [e-mail]
dr Peter Gresner
tel.: +48 58 349 1438 [e-mail]
dr Kamil Kowalski
tel.: +48 58 349 9019 [e-mail]
dr Beata Pieczyńska Uziębło
+48 58 349 1438 [e-mail]
dr Barbara Seroczyńska
tel.: +48 58 349 1438 [e-mail]
MSc Małgorzata Madej
tel.: +48 58 349 1438 [e-mail]
MSc Barbara Bollin-Matysiak
+48 58 349 9019 [e-mail]
Olesia Zabolotna
+48 58 349 9019 [e-mail]

PHD students:

MSc Robert Wenta
tel.: +48 58 349 1438 [e-mail]
MSc Justyna Topa
tel.: +48 58 349 1438 [e-mail]
MSc Agnieszka Stankiewicz
tel.: +48 58 349 1438 [e-mail]
MSc Julia Richert
tel.: +48 58 349 1438 [e-mail]
MSc Anna Muchlińska
tel.: +48 58 349 1438 [e-mail]
MSc eng. Maksym Jopek
tel.: +48 58 349 1438 [e-mail]
MSc Zuzanna Kulik
tel.: +48 58 349 1438 [e-mail]

 

PUBLICATIONS

  1. Xiao Xiang, Miao Xinxing, Duan Shanzhou, Liu Sidi, Cao Qinghua, Wu Renfei, Tao Chengcheng, Zhao Jian, Qu Qing, Markiewicz Aleksandra, Peng Rui, Chen Yongbing, Żaczek Anna, Liu Jian. Single-Cell Enzymatic Screening for Epithelial Mesenchymal Transition with an Ultrasensitive Superwetting Droplet-Array Microchip. Small Methods 2023, 7(7): e2300096 (doi: 10.1002/smtd.202300096)

  2. Cygert Sebastian, Pastuszak Krzysztof, Górski Franciszek, Sieczczyński Michał, Juszczyk Piotr, Rutkowski Antoni, Lewalski Sebastian, Różański Robert, Jopek Maksym Jopek, Jassem Jacek, Czyżewski Andrzej, Wurdinger Thomas, Best Myron G., Żaczek Anna J., Supernat Anna . Platelet-Based Liquid Biopsies through the Lens of Machine Learning. Cancers (Basel) 2023, 15(8): 2336 (doi: 10.3390/cancers15082336)

  3. Muchlińska Anna, Wenta Robert, Ścińska Wiktoria, Markiewicz Aleksandra, Suchodolska Grażyna, Senkus Elżbieta, Żaczek Anna, Bednarz-Knoll Natalia. Improved characterization of circulating tumor cells and cancer-associated fibroblasts in one-tube assay in breast cancer patients using imaging flow cytometry. Cancers 2023, 15(16): 4169 (doi: 10.3390/cancers15164169)

  4. Urbiola Salvador Victor, de Souza Suiane Lima, Grešner Peter, Qureshi Talha, Chen Zhi Jane. Plasma Proteomics Unveil Novel Immune Signatures and Biomarkers upon SARS-CoV-2 Infection. International Journal of Molecular Sciences 2023, 24(7): 6276 (doi: 10.3390/ijms24076276)

  5. Poli Alessandro, Pennacchio Fabrizio A., Ghisleni Andrea, di Gennaro Mariagrazia, Lecacheur Margaux, Nastały Paulina, Crestani Michele, Pramotton Francesca M., Iannelli Fabio, Beznusenko Galina, Mironov Alexander A., Panzetta Valeria, Fusco Sabato, Sheth Bhavwanti, Poulikakos Dimos, Ferrari Aldo, Gauthier Nils, Netti Paolo A., Divecha Nullin, Maiuri Paolo. PIP4K2B is mechanoresponsive and controls heterochromatin-driven nuclear softening through UHRF1. Nature Communications 2023, 14: 1432 (doi: 10.1038/s41467-023-37064-0)

  6. Bednarz-Knoll Natalia, Popęda Marta, Kryczka Tomasz, Kozakiewicz Barbara, Pogoda Katarzyna, Szade Jolanta, Markiewicz Aleksandra, Strzemecki Damian, Kalinowski Leszek, Skokowski Jarosław, Liu Jian, Żaczek Anna. Higher platelet counts correlate to tumour progression and can be induced by intratumoural stroma in non-metastatic breast carcinomas. British Journal of Cancer 2022, 126(3): 464-471 (doi: 10.1038/s41416-021-01647-9)

  7. Besler Katharina, Węglarz Aleksandra, Keller Laura, Von Amsberg Gunhild, Bednarz-Knoll Natalia, Offermann Anne, Stoupiec Sara, Eltze Elke, Semjonow Axel , Boettcher Lena, Schneegans Svenja, Perner Sven, Hauch Siegfried, Todenhöfer Tilman, Peine Sven, Pantel Klaus, Wikman Harriet, Werner Stefan. Expression patterns and corepressor function of retinoic acid-induced 2 in prostate cancer. Clinical Chemistry 2022, 68(7): 973-983 (doi: 10.1093/clinchem/hvac073)

  8. Kordulewska Natalia K., Topa Justyna , Rozmus Dominika, Jarmołowska Beata. Effects of osthole on inflammatory gene expression and cytokine secretion in histamine-induced inflammation in the Caco-2 cell line. International Journal of Molecular Sciences 2022, 22(24): 13634 (doi: 10.3390/ijms222413634)

  9. Krawczyk Katarzyna, Myszczyński Kamil, Nobis Marcin, Sawicki Jakub. Insights into adaptive evolution of plastomes in Stipa L. (Poaceae). BMC Plant Biology 2022, 22(1): 525 (doi: 10.1186/s12870-022-03923-z)

  10. Muchlińska Anna, Nagel Anna, Popęda Marta, Szade Jolanta, Niemira Magdalena, Zieliński Jacek, Skokowski Jarosław, Bednarz-Knoll Natalia, Żaczek Anna. Alpha-smooth muscle actin-positive cancer-associated fibroblasts secreting osteopontin promote growth of luminal breast cancer. Cellular & Molecular Biology Letters 2022, 27(1): 45 (doi: 10.1186/s11658-022-00351-7)

  11. Szandar Kamil, Krawczyk Katarzyna, Myszczyński Kamil, Ślipiko Monika, Sawicki Jakub, Szczecińska Monika. Breaking the limits - multichromosomal structure of an early eudicot Pulsatilla patens mitogenome reveals extensive RNA-editing, longest repeats and chloroplast derived regions among sequenced land plant mitogenomes. BMC Plant Biology 2022, 22(1): 109 (doi: 10.1186/s12870-022-03492-1)

  12. Muchlińska Anna, Richert Julia, Żaczek Anna, Bednarz-Knoll Natalia. Detection and characterization of circulating tumor cells using imaging flow cytometry - a perspective study. Cancers 2022, 14(17): 4178 (doi: 10.3390/cancers14174178)

  13. Duchnowska Renata, Supernat Anna, Pęksa Rafał, Łukasiewicz Marta, Stokowy Tomasz, Ronen Roy, Dutkowski Janusz, Umińska Monika, Iżycka-Świeszewska Ewa, Kowalczyk Anna, Och Waldemar, Rucińska Monika, Olszewski Wojciech P., Mandat Tomasz, Jarosz Bożena, Bieńkowski Michał, Biernat Wojciech, Jassem Jacek. Pathway-level mutation analysis in primary high-grade serous ovarian cancer and matched brain metastases. Scientific Reports 2022, 12: 20537 (doi: 10.1038/s41598-022-23788-4)

  14. Sakowska Justyna, Arcimowicz Łukasz, Jankowiak Martyna, Papak Ines, Markiewicz Aleksandra, Dziubek Katarzyna, Kurkowiak Małgorzata, Kote Sachin, Kaźmierczak-Siedlecka Karolina, Połom Karol, Marek-Trzonkowska Natalia, Trzonkowski Piotr. Autoimmunity and cancer-two sides of the same coin. Frontiers in Immunology 2022, 13: 793234 (doi: 10.3389/fimmu.2022.793234)

  15. Gao Yue, Liu Chun-Jie, Li Hua-Yi, Xiong Xiao-Ming, Li Gui-Ling, In ‘t Veld Sjors G J G, Cai Guang-Yao, Xie Gui-Yan, Zeng Shao-Qing, Wu Yuan, Chi Jian-Hua, Liu Jia-Hao, Zhang Qiong, Jiao Xiao-Fei, Shi Lin-Li, Lu Wan-Rong, Lv Wei-Guo, Yang  Xing-Sheng, Piek Jurgen M J,  D de Kroon Cornelis, Lok C A R, Supernat Anna, Łapińska-Szumczyk Sylwia, Łojkowska Anna, Żaczek Anna J., Jassem Jacek, Tannous Bakhos A, Sol Nik, Post Edward, Best Myron G, Kong Bei-Hua, Xie Xing, Ma Ding, Wurdinger Thomas, Guo An-Yuan, Gao Qing-Lei. Platelet RNA enables accurate detection of ovarian cancer: an intercontinental, biomarker identification study. Protein & Cell 2022, 14(8): 579-590 (doi: 10.1093/procel/pwac056)

  16. In 't Veld Sjors G.J.G., Arkani Mohammad, Post Edward, Antunes-Ferreira Mafalda, D'Ambrosi Silvia, Vessies Daan C. L., Vermunt Lisa, Vancura Adrienne, Muller Mirte, Niemeijer Anna-Larissa N., Tannous Jihane, Meijer Laura L., Le Large Tessa Y. S., Mantini Giulia, Wondergem Niels E., Heinhuis Kimberley M., van Wilpe Sandra, Smits A. Josien, Drees Esther E. E., Roos Eva, Leurs Cyra E., Tjon-Kon-Fat Lee-Ann, van der Lelij Ewoud J., Dwarshuis Govert, Kamphuis Maarten J., Visser Lissane E., Harting Romee, Gregory Annemijn, Schweiger Markus W., Wedekind Laurine E., Ramaker Jip, Zwaan Kenn, Verschueren Heleen, Bahce Idris, de Langen Adrianus J., Smit Egbert F., van den Heuvel Michel M., Hartemink Koen J., Kuijpers Marijke J. E., oude Egbrink Mirjam G. A., Griffioen Arjan W., Rossel Rafael, Hiltermann T. Jeroen N., Lee-Lewandrowski Elizabeth, Lewandrowski Kent B., De Witt Hamer Philip C., Kouwenhoven Mathilde, Reijneveld Jaap C., Leenders Wiliam P. J., Hoeben Ann, Verdonck-de Leeuw Irma M., Leemans C. René, Baatenburg de Jong Robert J., Terhaard Chris H. J., Takes Robert P., Langendijk Johannes A., de Jager Saskia C., Kraaijeveld Adriaan O., Pasterkamp Gerard, Smits Minke, Schalken Jack A., Łapińska-Szumczyk Sylwia, Łojkowska Anna, Żaczek Anna, Lokhorst Henk, van de Donk Niels W.C.J., Nijhof Inger, Prins Henk-Jan, Zijlstra Josée M., Idema Sander, Baayen Johannes C., Teunissen Charlotte E., Killestein Joep, Besselink Marc G., Brammen Lindsay, Bachleitner-Hofmann Thomas, Mateen Farrah, Plukker John T.M., Heger Michal, de Mast Quirijn, Lisman Ton, Pegtel D. Michiel, Bogaard Harm-Jan, Jassem Jacek, Supernat Anna, Mehra Niven, Gerritsen Winald, de Kroon Cornelis D., Lok Christianne A. R., Piek Jurgen M. J., Steeghs Neeltje, van Houdt Winan J., Brakenhoff Ruud H., Sonke Gabe S., Verheul Henk M., Giovannetti Elisa, Kazemier Geert, Sabrkhany Siamack, Schuuring Ed, Sistermans Erik A., Wolthuis Rob, Meijers-Heijboer Hanne, Dorsman Josephine, Oudejans Cees, Ylstra Bauke, Westerman Bart A., van den Broek Daan, Koppers-Lalic Danijela, Wesseling Pieter, Nilsson R. Jonas A., Vandertop W. Peter, Noske David P., Tannous Bakhos A., Sol Nik, Best Myron G., Wurdinger Thomas. Detection and localization of early- and late-stage cancers using platelet RNA. Cancer Cell 2022, 40(9): 999-1009.e6 (doi: 10.1016/j.ccell.2022.08.006)

  17. Nagel Anna, Popęda Marta, Muchlinska Anna, Sądej Rafał, Szade Jolanta, Zieliński Jacek, Skokowski Jarosław, Niemira Magdalena, Kretowski Adam, Markiewicz Aleksandra, Żaczek Anna J.. ER alpha 36-High Cancer-Associated Fibroblasts as an Unfavorable Factor in Triple-Negative Breast Cancer. Cancers 2022, 14(8): 2005 (doi: 10.3390/cancers14082005)

  18. Mieczkowski Kamil, Kitowska Kamila, Braun Marcin, Galikowska-Bogut Barbara, Górska-Arcisz Monika, Piasecka Dominika, Stawiski Konrad, Żaczek Anna J., Nejc Dariusz, Kordek Radzisław, Romanska Hanna M., Sądej Rafał. FGF7/FGFR2-JunB signalling counteracts the effect of progesterone in luminal breast cancer. Molecular Oncology 2022, 16(15): 2823-2842 (doi: 10.1002/1878-0261.13274).

  19. Panasiuk Mirosława, Zimmer Karolina, Czarnota Anna, Narajczyk Magdalena, Peszyńska-Sularz Grażyna, Chraniuk Milena, Hovhannisyan Lilit, Żołędowska Sabina, Nidzworski Dawid, Żaczek Anna, Gromadzka Beata. Chimeric virus-like particles presenting tumour-associated MUC1 epitope result in high titers of specific IgG antibodies in the presence of squalene oil-in-water adjuvant: towards safe cancer immunotherapy. Journal of Nanobiotechnology 2022, 20(1): 160 (doi: 10.1186/s12951-022-01357-1)
  20. Topa Justyna, Grešner Peter, Żaczek Anna, Markiewicz Aleksandra. Breast cancer circulating tumor cells with mesenchymal features—an unreachable target? Cellular and Molecular Life Sciences 2022, 79: 2 (doi: 10.1007/s00018-021-04064-6)
  21. Pennacchio Fabrizio A., Nastały Paulina, Poli Alessandro, Maiuri Paolo. Tailoring cellular function: the contribution of the nucleus in mechanotransduction. Frontiers in Bioengineering and Biotechnology 2021, 8: 596746 (doi: 10.3389/fbioe.2020.596746)
  22. Szade Jolanta, Kunc Michał, Pieczyńska-Uziębło Beata, Świerblewski Maciej, Biernat Wojciech, Jassem Jacek, Senkus-Konefka Elżbieta. Comparison of claudin-3 and claudin-4 expression in bilateral and unilateral breast cancer. Neoplasma 2021, 68(2): 283-289 (doi: 10.4149/neo_2020_200816N867)
  23. Pastuszak Krzysztof, Supernat Anna, Best Myron G., Veld  Sjors G.J.G. In 't, Łapińska-Szumczyk Sylwia, Łojkowska Anna, Różański Robert, Żaczek Anna J., Jassem Jacek, Würdinger Thomas, Stokowy Tomasz. imPlatelet classifier: image-converted RNA biomarker profiles enable blood-based cancer diagnostics. Molecular Oncology 2021, 15(10): 2688-2701 (doi: 10.1002/1878-0261.13014)
  24. Nastały Paulina, Richert Julia, Popęda Marta, Martini Emanuele, Maiuri Paolo, Żaczek Anna, Sowa Marek, Matuszewski Marcin, Szade Jolanta, Kalinowski Leszek, Niemira Magdalena, Brandt Burkhard, Eltze Elke, Semjonow Axel, Bednarz-Knoll Natalia. Low tumor-to-stroma ratio reflects protective role of stroma against prostate cancer progression. Journal of Personalized Medicine 2021, 11(11): 1088 (doi: 10.3390/jpm11111088)
  25. Markiewicz Aleksandra, Topa Justyna, Popęda Marta, Szade Jolanta, Skokowski Jarosław, Wełnicka-Jaśkiewicz Marzena, Żaczek Anna. Activation of epithelial-mesenchymal transition process during breast cancer progression : the impact of molecular subtype and stromal composition. Acta Biochimica Polonica 2021, 68(3): 385-392 (doi: 10.18388/abp.2020_5719)
  26. Krupa Łukasz, Staroń Robert, Dulko Dorota, Łozińska Natalia, Mackie Alan T., Rigby Nail M., Macierzanka Adam, Markiewicz Aleksandra, Jungnickel Christian. Importance of bile composition for diagnosis of biliary obstructions. Molecules 2021, 16(23): 7279 (doi: 10.3390/molecules26237279)
  27. Kordulewska Natalia K., Topa Justyna, Tańska Małgorzata, Cieślińska Anna, Fiedorowicz Ewa, Savelkoul Huub F. J., Jarmołowska Beata. Modulatory effects of osthole on lipopolysaccharides-induced inflammation in Caco-2 cell monolayer and co-cultures with THP-1 and THP-1-derived macrophages. Nutrients 2021, 13(1): 123 (doi: 10.3390/nu13010123)
  28. Popęda Marta, Markiewicz Aleksandra, Stokowy Tomasz, Szade Jolanta, Niemira Magdalena, Kretowski Adam, Bednarz-Knoll Natalia, Żaczek Anna J.. Reduced expression of innate immunity-related genes in lymph node metastases of luminal breast cancer patients. Scientific Reports 2021, 11(1): 5097 (doi: 10.1038/s41598-021-84568-0)
  29. Pantano Francesco, Croset Martine, Driouch Keltouma, Bednarz-Knoll Natalia, Iuliani Michele, Ribelli Giulia, Bonnelye Edith, Wikman Harriet, Geraci Sandra, Bonin Florian, Simonetti Sonia, Vincenzi Bruno, Hong Saw See, Sousa Sofia, Pantel Klaus, Tonini Giuseppe, Santini Daniele, Clézardin Philippe. Integrin alpha5 in human breast cancer is a mediator of bone metastasis and a therapeutic target for the treatment of osteolytic lesions. Oncogene 2021, 40(7): 1284-1299 (doi: 10.1038/s41388-020-01603-6)
  30. Nastały Paulina, Stoupiec Sara, Popęda MartaSmentoch Julia, Schlomm Thorsten, Morrissey Colm, Żaczek Anna J., Beyer Burkhard, Tennstedt Pierre, Graefen Markus, Eltze Elke, Maiuri Paolo, Semjonow Axel, Pantel Klaus, Brandt Burkhard, Bednarz-Knoll Natalia. EGFR as a stable marker of prostate cancer dissemination to bones. British Journal of Cancer 2020, 123(12): 1767-1774(doi: 10.1038/s41416-020-01052-8)
  31. Kunc Michał, Popęda  Marta, Niemira  Magdalena, Szałkowska  Anna, Bieńkowski Michał, Peksa Rafał, Lacko Aleksandra, Radecka Barbara S., Braun Marcin, Pikiel Joanna, Litwiniuk Maria, Pogoda Katarzyna, Izycka-Swieszewska Ewa, Kretowski Adam, Żaczek Anna J., Biernat Wojciech, Senkus-Konefka Elzbieta. microRNA Expression Profile in Single Hormone Receptor-Positive Breast Cancers is Mainly Dependent on HER2 Status-A Pilot Study. Diagnostics 2020, 10(9): 617 (doi:10.3390/diagnostics10090617)
  32. Bieńkowski Michał, Peksa Rafał, Popęda Marta, Kolaczkowska Magdalena, Frankiewicz Anna, Żaczek Anna, Gruchała Marcin, Biernat Wojciech, Siondalski Piotr. Liquid biopsy for minimally invasive heart transplant monitoring: a pilot study. Journal of Clinical Pathology 2020, 73(8): 507-510 (doi:10.1136/jclinpath-2019-205926)
  33. Fabisiewicz Anna, Szostakowska-Rodzos Malgorzata, Żaczek Anna J., Grzybowska Ewa A.. Circulating Tumor Cells in Early and Advanced Breast Cancer; Biology and Prognostic Value. International Journal of Molecular Sciences 2020, 21(5): 1671 (doi: 10.3390/ijms21051671)
  34. Brandt Burkhard H.,  Bednarz-Knoll Natalia,  Kleinheinz Johannes,  Franke Andre,  Fillies Thomas. RE: Oral Leukoplakia and Risk of Progression to Oral Cancer: A Population-Based Cohort Study. JNCI-Journal of the National Cancer Institute 2020, 112(9): 968-969 (doi: 10.1093/jnci/djaa074)
  35. Montfort Anne, Owen Stephanie, Piskorz Anna M., Supernat Anna, Moore Luiza, Al-Khalidi Sarwah, Bohm Steffen, Pharoah Paul, McDermott Jacqueline, Balkwill Frances R., Brenton James D. Combining measures of immune infiltration shows additive effect on survival prediction in high-grade serous ovarian carcinoma. British Journal of Cancer 2020, (w druku)  (doi: 10.1038/s41416-020-0822-x)
  36. Markiewicz AleksandraTopa Justyna, Nagel Anna, Skokowski Jarosław, Seroczynska Barbara, Stokowy Tomasz, Welnicka-Jaskiewicz Marzena, Żaczek Anna J.. Spectrum of Epithelial-Mesenchymal Transition Phenotypes in Circulating Tumour Cells from Early Breast Cancer Patients. Cancers 2019, 11(1): 59 (doi: 10.3390/cancers11010059)
  37. Nagel Anna, Szade Jolanta, Iliszko Mariola, Elzanowska Julia, Welnicka-Jaskiewicz Marzena, Skokowski Jarosław, Stasiłojć Grzegorz, Bigda Jacek, Sądej Rafał, Żaczek Anna, Markiewicz Aleksandra. Clinical and Biological Significance of ESR1 Gene Alteration and Estrogen Receptors Isoforms Expression in Breast Cancer Patients. International Journal of Molecular Sciences 2019, 20(8): 1881 (doi: 10.3390/ijms20081881)
  38. Ouyang Fuzhong, Yu Tianrong, Gu Chao, Wang Guanghui, Shi Rui, Lv Rui, Wu Enhui, Ma Chongqing, Guo Ruochen, Li Jing, Żaczek Anna, Liu Jian. Sensitive detection of caspase-3 enzymatic activities and inhibitor screening by mass spectrometry with dual maleimide labelling quantitation. Analyst 2019, 144(22): 6751-6759 (doi: 10.1039/c9an01458f)
  39. Smolle Anna Maria, Czapiewski Piotr, Łapińska-Szumczyk Sylwia, Majewska Hanna, Supernat Anna Maria, Żaczek Anna, Biernat Wojciech, Golob-Schwarzl Nicole, Haybaeck Johannes. The prognostic significance of eukaryotic translation initiation factors (eIFs) in endometrial cancer. International Journal of Molecular Sciences 2019, 20(24): 6169 (doi: 10.3390/ijms20246169)
  40. Smentoch Julia Szade Jolanta, Żaczek Anna, Eltze Elke, Semjonow Axel, Brandt Bukhard, Bednarz-Knoll Natalia. Low Numbers of Vascular Vessels Correlate to Progression in Hormone-Naïve Prostate Carcinomas Undergoing Radical Prostatectomy. Cancers 2019, 11(9): 1356 (doi: 10.3390/cancers11091356)
  41. Braun Marcin, Markiewicz Aleksandra, Kordek Radzisław, Sądej Rafał, Romańska Hanna.. Profiling of invasive breast carcinoma circulating tumour cells : are we ready for the "liquid" revolution? Cancers 2019, 11(2): 143 (doi: 10.3390/cancers11020143)
  42. Popęda Marta, Stokowy Tomasz, Bednarz-Knoll Natalia, Jurek Anna, Niemira Magdalena, Bielska Agnieszka, Kretowski Adam, Kalinowski Leszek, Szade Jolanta, Markiewicz Aleksandra, Żaczek Anna . NF-kappa B Signaling-Related Signatures Are Connected with the Mesenchymal Phenotype of Circulating Tumor Cells in Non-Metastatic Breast Cancer. Cancers 2019, 11(12): 1961 (doi: 10.3390/cancers11121961)
  43. Szade Jolanta, Majewska Hanna, I., Żaczek Anna, Biernat Wojciech. High-grade non-small cel lung carcinoma: a comparative analysis of the phenotypic profile in small biopsies with the corresponding postoperative material. Polish Journal of Pathology 2019, 70(2): 100-108 (doi: 10.5114/PJP.2019.84087)
  44. Czaplińska Dominika, Górska Monika, Mieczkowski Kamil, Peszynska-Sularz Grazyna, Żaczek Anna J., Romanska Hanna M., Sądej Rafał, RSK1 promotes murine breast cancer growth and metastasis. Folia Histochemica et Cytobiologica 2018, 56(1): 11-20 (doi: 10.5603/FHC.a2018.0001)
  45. Filipska Martyna, Skrzypski Marcin, Czetyrbok Katarzyna, Stokowy Tomasz, Stasiłojć Grzegorz, Supernat Anna, Jassem Jacek, Żaczek Anna J., Bigda Jacek. MiR-192 and miR-662 enhance chemoresistance and invasiveness of squamous cell lung carcinoma. Lung Cancer 2018, 118: 111-118 (doi: 10.1016/j.lungcan.2018.02.002)
  46. Markiewicz Aleksandra, Nagel Anna, Szade Jolanta, Majewska Hanna, Skokowski Jaroslaw, Seroczynska Barbara, Stokowy Tomasz, Welnicka-Jaskiewicz Marzena, Żaczek Anna J. Aggressive Phenotype of Cells Disseminated via Hematogenous and Lymphatic Route in Breast Cancer Patients. Translational Oncology2018, 11(3): 722-731 (doi: 10.1016/j.tranon.2018.03.006)
  47. Shen Rui, Liu Peipei, Zhang Yiqiu, Yu Zhao, Chen Xuyue, Zhou Lu, Nie Baoqing, Żaczek Anna J., Chen Jian, Liu Jian. Sensitive detection of single-cell secreted H2O2 by integrating a microfluidic droplet sensor and Au nanoclusters. Analytical Chemistry 2018, 90(7): 4478-4484 (doi: 10.1021/acs.analchem.7b04798)
  48. Markiewicz Aleksandra, Żaczek Anna J. The Landscape of Circulating Tumor Cell Research in the Context of Epithelial-Mesenchymal Transition. Pathobiology 2017, 84(5): 264-283 (doi: 10.1159/000477812)
  49. Czapiewski Piotr, Bobowicz Maciej, Peksa Rafal, Skrzypski Marcin, Gorczynski Adam, Szczepanska-Michalska Kamila-Korwat Aleksandra, Jankowski Michal, Zegarski Wojciech, Szulgo-Paczkowska Anna, Polec TomaszPiatek MichalSkokowski JaroslawHaybaeck, Johannes, Żaczek Anna J., Biernat Wojciech. Kreatin 7 expression in lymph node metastases but not in the primary tumor correlates with distant metastases and poor prognosis in colon carcinoma. Polish Journal of Pathology  2016, 67: 228-234 (doi: 10.5114/PJP.2016.63774
  50. Czaplińska DominikaMieczkowski KamilSupernat Anna,  Skladanowski Andrzej C., Kordek Radzislaw, Biernat Wojciech, Żaczek Anna J., Romanska Hanna M., Sądej Rafał. Interactions between FGFR2 and RSK2—implications for breast cancer prognosis, Tumor Biology 2016, 37: 13721-13731 (doi: 10.1007/s13277-016-5266-9)
  51. Łapińska-Szumczyk Sylwia, Supernat Anna, Żaczek Anna, Majewska Hanna, Gulczyński Jacek, Sawicki Sambor, Biernat Wojciech, Wydra Dariusz. Endometrial cancer in patients after previous neoplasmatic disease – clinical and molecular aspects. Ginekologia Polska 2016, 87(2): 88-93 (doi: 10.17772/gp/60559)
  52. Łuczak Agata, Supernat Anna, Łapińska-Szumczyk Sykwia, Jachimowicz Daniel, Majewska Hanna, Gulczyński Jacek , Żaczek Anna. HOTAIR in relation to epithelial-mesenchymal transition and cancer stem cells in molecular subtypes of endometrial cancer. International Journal of Biological Markers 2016, 31(3): e245-e251 (doi: 10.5301/jbm.5000187)
  53. Piasecka Dominika, KitowskaKamila, Czaplinska Dominika, Mieczkowski Kamil, Mieszkowska Magdalena, Turczyk Łukasz, Składanowski Andzej C., Żaczek Anna J., Biernat Wojciech, Kordek Radzisław, Romanska Hanna M., Sądej Rafał. Fibroblast growth factor signalling induces loss of progesterone receptor in breast cancer cells. Oncotarget 2016, 7(52): 86011-86025 (doi: 10.18632/oncotarget.13322)
  54. Bednarz-Knoll Natalia, Nastały Paulina, Żaczek Anna, Stoupiec Małgorzata, Riethdorf Sabine, Wikman Harriet, Müller Volkmar, Skokowski Jarosław, Szade Jolanta, Sejda Aleksandra, Wełnicka-Jaśkiewicz Marzena, Pantel Klaus. Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression. Oncotarget 2015, 6(29): 26789-26803 (doi: 10.18632/oncotarget.4628).
  55. apiewski Piotr, Wełnicka-Jaśkiewicz Marzena, Seroczyńska Barbara, Skokowski Jarosław, Sejda Aleksandra, Szade Jolanta, Wiewiora Claudia, Biernat Wojciech, Żaczek Anna. CD99 correlates with low cyclin D1, high topoisomerase 2α status and triple negative molecular phenotype but is prognostically irrelevant in breast carcinoma. Polish Journal of Pathology 2015, 66(3): 269-275 (doi: 10.5114/pjp.2015.54961).
  56. Łapińska-Szumczyk Sylwia M., Supernat Anna M., Majewska Hanna I., Gulczyński Jacek, Biernat Wojciech, Wydra Dariusz, Żaczek Anna J. Immunohistochemical characterisation of molecular subtypes in endometrial cancer. International Journal of Clinical and Experimental Medicine 2015, 8(11): 21981-21990
  57. Czaplińska DominikaTurczyk ŁukaszGrudowska AlicjaMieszkowska MagdalenaLipińska Andrea D.Składanowski Andrzej C.Żaczek Anna J., Romańska Hanna M., Sądej Rafał. Phosphorylation of RSK2 at Tyr529 by FGFR2-p38 enhances human mammary epithelial cells migration. Biochimica et Biophysica Acta-Molecular Cell Research 2014, 1843(11): 2461-2470 (doi: 10.1016/j.bbamcr.2014.06.022).
  58. Łapińska-Szumczyk Sylwia, Supernat Anna, Majewska Hanna, Gulczyński Jacek, Łuczak Agata, Biernat Wojciech, Wydra Dariusz, Żaczek Anna J. HER2-positive endometrial cancer subtype carries poor prognosis. CTS-Clinical and Translational Science 2014, 7(6): 482-488 (doi: 10.1111/cts.12207).
  59. Łapińska-Szumczyk Sylwia, Supernat AnnaŻaczek Anna J., Majewska Hanna, Gulczyński Jacek, Sawicki Sambor, Biernat Wojciech, Wydra Dariusz. Rak błony śluzowej trzonu macicy u młodych kobiet – aspekty kliniczne i molekularne [Endometrial cancer in young women - clinical and molecular aspects]. Ginekologia Polska 2014, 85(9): 754-759.
  60. Markiewicz Aleksandra, Wełnicka-Jaśkiewicz Marzena, Seroczyńska Barbara, Skokowski Jarosław, Majewska Hanna, Szade Jolanta, Żaczek Anna J. Epithelial-mesenchymal transition markers in lymph node metastases and primary breast tumors - Relation to dissemination and proliferation. American Journal of Translational Research 2014, 6(60: 793-808 (pdf).
  61. Markiewicz AleksandraKsiążkiewicz Magdalena, Wełnicka-Jaśkiewicz Marzena, Seroczyńska Barbara, Skokowski Jarosław, Szade Jolanta, Żaczek Anna J. Mesenchymal phenotype of CTC-enriched blood fraction and lymph node metastasis formation potential. PLoS ONE 2014, 9(4): art. no e93901 (1-11) (doi: 10.1371/journal.pone.0093901).
  62. Senkus Elżbieta, Szade Jolanta, Pieczyńska Beata, Żaczek Anna, Pikiel Joanna, Sosińska-Mielcarek Katarzyna, Karpińska Agnieszka, Jassem Jacek. Are synchronous and metachronous bilateral breast cancers different? An immunohistochemical analysis aimed at intrinsic tumor phenotype. International Journal of Clinical and Experimental Pathology 2014, 7(1): 353-363 (pdf).
  63. Senkus Elżbieta, Szade Jolanta, Pieczyńska Beata, Żaczek Anna, Świerblewski Maciej, Biernat Wojciech, Jassem Jacek. Are bilateral breast cancers and breast cancers coexisting with ovarian cancer different from solitary tumors? A pair-matched immunohistochemical analysis aimed at intrinsic tumor phenotype. Pathology International 2014, 64(10): 508-517 (doi: 10.1111/pin.12202).
  64. Supernat Anna, Łapińska-Szumczyk Sylwia, Majewska Hanna, Gulczyński Jacek, Biernat Wojciech, Wydra Dariusz, Żaczek Anna J. A multimarker qPCR platform for the characterisation of endometrial cancer. Oncology Reports 2014, 31(2): 1003-1013 (doi: 10.3892/or.2013.2924).
  65. Supernat Anna, Łapińska-Szumczyk Sylwia, Majewska Hanna, Gulczyński Jacek, Biernat Wojciech, Wydra Dariusz, Żaczek Anna J. Tumor Heterogeneity at Protein Level as an Independent Prognostic Factor in Endometrial Cancer. Translational Oncology 2014, 7(5): 613-619 (doi: 10.1016/j.tranon.2014.06.001).
  66. Markiewicz Aleksandra, Książkiewicz Magdalena, Seroczyńska Barbara, Skokowski Jarosław, Szade Jolanta, Wełnicka-Jaśkiewicz Marzena, Żaczek Anna J. Heterogeneity of mesenchymal markers expression-molecular profiles of cancer cells disseminated by lymphatic and hematogenous routes in breast cancer. Cancers 2013, 5(4): 1485-1503
  67. Markiewicz Aleksandra, Wełnicka-Jaśkiewicz Marzena, Skokowski Jarosław, Jaśkiewicz Janusz, Szade Jolanta, Jassem Jacek, Żaczek Anna J. Prognostic Significance of ESR1 Amplification and ESR1 PvuII, CYP2C19*2, UGT2B15*2 Polymorphisms in Breast Cancer Patients. PLoS ONE 2013, 8(8): art. no: e72219 (1-10)
  68. Senkus Elżbieta, Szade Jolanta, Pieczyńska Beata, Żaczek Anna, Brożek Izabela, Radecka Barbara, Kowalczyk Anna, Wełnicka-Jaśkiewicz Marzena, Jassem Jacek. Are bilateral breast cancers different from breast cancers coexisting with ovarian cancer? An immunohistochemical analysis aimed at intrinsic tumor phenotype. Breast 2013, 22(4): 425-430
  69. Supernat Anna, Łapińska-Szumczyk Sylwia, Majewska Hanna, Gulczyński Jacek, Biernat Wojciech, Wydra Dariusz, Żaczek Anna J. Epithelial-mesenchymal Transition and Cancer Stem Cells in Endometrial Cancer. Anticancer Research 2013, 33(12): 5461-5469
  70. Książkiewicz Magdalena, Markiewicz Aleksandra, Żaczek Anna J. Epithelial-mesenchymal transition: A hallmark in metastasis formation linking circulating tumor cells and cancer stem cells. Pathobiology 2012, 79(4): 195-208
  71. Markiewicz Aleksandra, Ahrends Tomasz, Wełnicka-Jaśkiewicz Marzena, Seroczyńska Barbara, Skokowski Jarosław, Jaśkiewicz Janusz, Szade Jolanta, Biernat Wojciech, Żaczek Anna. Expression of epithelial to mesenchymal transition-related markers in lymph node metastases as a surrogate for primary tumor metastatic potential  in breast cancer. Journal of Translational Medicine 2012, 10: art. no 226 (1-12)
  72. Supernat A., Łapińska-Szumczyk S., Sawicki S., Wydra D., Biernat W., Żaczek A. Deregulation of RAD21 and RUNX1 expression in endometrial cancer. Oncology Letters 2012, 4(4): 727-732
  73. Supernat Anna, Markiewicz Aleksandra, Wełnicka-Jaśkiewicz Marzena, Seroczyńska Barbara, Skokowski Jarowsław, Sejda Aleksandra, Szade Jolanta, Czapiewski Piotr, Biernat Wojciech, Żaczek Anna. CD73 Expression as a Potential Marker of Good Prognosis in Breast Carcinoma. Applied Immunohistochemistry & Molecular Morphology 2012, 20(2): 103-107
  74. Żaczek A.J.Markiewicz A., Seroczyńska B., Skokowski J., Szade J., Jaśkiewicz J., Pieńkowski T. Olszewski W.P., Rhone P., Wełnicka-Jaśkiewicz M., Jassem J. Prognostic significance of TOP2A gene dosage in HER2-negative breast cancer. Oncologist 2012, 17(10): 1246-1255
  75. Żaczek Anna, Markiewicz Aleksandra, Supernat Anna, Bednarz-Knoll Natalia, Brandt Burkhardt, Seroczyńska Barbara, Skokowski Jarosław, Szade Jolanta, Czapiewski Piotr, Biernat Wojciech, Wełnicka-Jaśkiewicz Marzena, Jassem Jacek. Prognostic Value of TOP2A Gene Amplification and Chromosome 17 Polysomy in Early Breast Cancer. Pathology & Oncology Research 2012, 18(4): 885-894
  76. Supernat Anna, Wełnicka-Jaśkiewicz Marzena, Żaczek Anna. Farmakogenetyka w hormonoterapii raka piersi [Pharmacogenetics in breast cancer hormone therapy]. Współczesna Onkologia (Contemporary Oncology) 2010, 14(4): 242-247
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Submitted on Wednesday, 5. February 2020 - 12:24 by Maria Maja Pega Changed on Monday, 4. September 2023 - 12:43 by Maria Maja Pega